Before becoming a district of Ho Chi Minh City, Chợ Lớn was a city in its own right, independent from Sài Gòn for over two centuries. Its story begins far from tourism: in flight, rebuilding, and trade.
Chinese Ming loyalists refusing the new Qing dynasty, led by general Trần Thượng Xuyên, get permission from the Nguyễn lords to settle in the south. Their descendants travel up the Đồng Nai river and found a first trading post on the bank of what would become Sài Gòn.
The Minh Hương Chinese community settles here fleeing repression by Tây Sơn troops, who accuse them of supporting the Nguyễn lords. In 1782, a Tây Sơn raid kills more than 10,000 Hoa people. Survivors rebuild their town on raised embankments — đê — which may be the origin of the name Đề Ngạn, "the embankment," pronounced Tai-Ngon by the Chinese.
Chợ Lớn — "the big market" — is officially established, about 11 km from Sài Gòn.
The French take Cochinchina and find an already well-established Chinese community. Rather than administering it directly, they organize it into five "congregations" matching the main dialect groups, who run their own schools, hospitals and cemeteries. A tram line, then boulevards, connect Sài Gòn and Chợ Lớn — at the cost of filling in the Chợ Lớn canal and its waterways in 1925, cutting merchants off from their boats and breaking the geomantic alignment of several temples.
Chợ Lớn loses its status as an independent city and merges with Sài Gòn to form "Sài Gòn – Chợ Lớn," a name simplified to plain "Sài Gòn" in 1956.
In the middle of a coup attempt, President Ngô Đình Diệm flees the presidential palace and takes refuge in Cha Tam church, right in Chợ Lớn. He is arrested there the following morning, then executed in the armored vehicle meant to bring him back to the city.
During the Tết Offensive, Chợ Lớn and the nearby Phú Thọ racetrack become one of the main urban fronts of Saigon. Street fighting between US/South Vietnamese forces and the Viet Cong stretches over several weeks and leaves the district heavily damaged.
Chợ Lớn corresponds to the former Districts 5 and 6 of Ho Chi Minh City. Despite a recent administrative reshuffle of the city's wards, the name Chợ Lớn remains the reference everyone still uses — a rare case of a popular place name outliving the official map.